Dengue are in danger because of dengue

virus is a well-known infection. It is caused by four types of viruses mainly
DENV-1, DENV-2, DENV-3, and DENV-4 come from the Flaviviridae family. The
viruses are spread through the bite of infected Aedes aegypti mosquitoes that
feed throughout the day. Mostly, these mosquitoes can be found in places with
stagnant water, including water tanks, tires, containers, and puddles. Some
effects of this infection are flu-like illness and lethal disease which is
severe dengue.

recent years, the cases of dengue have risen excessively around the world. An
estimated 390 million dengue cases are reported per year, 96 million shown
clearly. Another report, of frequentness of dengue, calculated 3.8 billion
people, in 128 countries are in danger because of dengue viruses. The incidence
of dengue cases recounted, elevated from 2.2 million to 3.2 million in 2010 to
2015 respectively. Although the global encumbers of infection is unstable, the
installation of activities to account initially illustrates the due accretion
in the number of cases recorded in preceding years. More than 100 countries in
the WHO regions of Africa, America, the Eastern Mediterranean, South-East Asia,
and the Western Pacific regions are facing this problem. Previously the number
of recorded cases has resumed arising. Almost 2.3 million cases of dengue were
recorded only in America in 2015. 10 300 cases were recognized as severe dengue
resulting 1180 deaths (Bhatt S, 2015).

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the Philippines has declared dengue cases. Regions where most affected by
dengue are Central Visayas, Central Luzon, Calabarzon, Metro Manila and
Soccsksargen. Dengue happens nationally and done throughout the year in the
Philippines especially in urban and pre-urban places. Transmission of the
infection happens throughout the rainy season, May down to November
(International Association for Medical Assistance to travelers, 2016). 43, 780
cases, 250 deaths and 85 casualties were reported and recorded by the
Department of Health. Generally, there were 6,281 dengue cases in Central
Visayas, 5,146 in Central Luzon, 5,008 in Calabarzon, 5,565 in Metro Manila,
and 4,863 in Soccsksargen. There also provinces affected by dengue virus
including Cebu (12%), South Cotabato (6.4%), and Pampanga (4.7%) (The Manila

there is also a number of dengue cases. According to the annual morbidity
record of Maco Main Health Center in September 2017, there are 4 people were
affected by dengue in Maco.


Review Related Literature

Calamansi is a little, spherical citrus fruit that is common in the
Philippines. Calamansi, also known as Citrofortunella microcarpa come from
Rutaceae family and a popular citrofortunella because it is an intergenetic
hybrid between the trait of a citrus and Kumquat. Throughout the world, there
are popular names for calamansi including calamonding, calamondin orange,
golden lime, and Philippine lime. It is broadly cultured in many places around
the world involving Philippines, Malaysia, Indonesia and China. The
availability of this fruit can sustain from beginning to the end of the year in
the Philippines. Some people used it for decoration or as an ornamental tree
than to look it as a fruit-bearing tree. The size of the Calamansi fruit goes
to 23-35 mm in diameter. The color of the pulp of an ripen Calamansi and its
peel is orange ( Retrieved: January 6, 2018).

Calamansi’s lime juice has
many benefits, it has a pectin content that can treat cough and cold and can
lower blood            cholesterol, also
it is abundant in Vitamin C that can prevent tooth decay and pain, dental
caries, releasing of blood in the gums and weakening of bones (
Retrieved: January 6, 2018)

Moreover, Calamansi peel
have four well-known hydroxycinnamic acids including caffeic, ferulic,
p-coumaric and sinapic acids that were considered in the methanolic extracts.
It held the largest number of total phenolic acids. Phenolic acid is a kind of
chemical compound as betacarotene called a polyphenol. Polyphenols has other
types like flavonoids and stilbenes (
Retrieved: January 6, 2018).

The phenolic compounds 2,6-diiodophenol (2a) and
4-chloro-2,6-diiodophenol (2c) have different toxicity and larvicidal
behaviour. The compound 4-chloro-2,6-diiodophenol (2c) showed the highest
toxicity for larvae of Ae. aegypti and A. salina, exhibiting higher toxicity
than 2,6-diiodophenol ( Retrieved: January 6, 2018).


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